Good morning ladies and gentlemen, my colleagues and I have called you in at such short notice because we need to discuss a patient who was brought to our attention earlier this week. The patient presented with rapidly progressing lymphadenopathy, subsequent examination lymph nodes congested with many small B-lymphocytes. The B-lymphocytes showed a significant chromosomal aberration in the form a 14;18 translocation. The patient has been diagnosed with lymphoma and has been prescribed an immediate course …showed first 75 words of 669 total…

…showed last 75 words of 669 total…is complete P53 goes away and the cell progresses into Interphase. If there is major DNA damage, P53 is continuously induced (in the absence of ATM) and promotes apoptosis by either directly activating death genes like BAX or by down-regulating survival genes like BCL-2. Errors in these checkpoints often lead to conditions like the lymphoma presented in the patient in question. Dr Lucia/Cath will provide an insight into what happens when things go wrong.