Axis formation is established very early in the development of vertebrates. Much research has been done in this area, especially with Xenopus, and the consensus is that the dorsal lip plays a key role in establishing the dorsal-ventral and anterior-posterior axes and organizing the develoment of the organism. Pioneering experiments were done by Spemann and Mangold in the 1920's: by transplanting a dorsal lip from one embryo to a point opposite the native dorsal lip …showed first 75 words of 556 total…

…showed last 75 words of 556 total…