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…showed last 75 words of 416 total…mother. The incidence of Down syndrome in children born to 25-year-old mothers is approximately 1 in 1200; the risk increases to approximately 1 in 350 for 35-year-olds and approximately 1 in 120 for women older than 40 years. Prenatal tests can be used to detect chromosome abnormality causing Down syndrome. SOURCES 1) 'Down Syndrome,' Microsoft(R) Encarta(R) 96 Encyclopedia. (c) 1993-1995 Microsoft Corporation. All rights reserved. (c) Funk & Wagnalls Corporation. All rights reserved. 2) 'Down Syndrome,' Encyclopedia of Sleep and Dreaming.